150-600 mg daily in 2 or 3 divided doses.
Neuropathic pain Initially 150 mg daily given as 2 or 3 divided doses, may be increased to 300 mg daily after an interval of 3-7 days. Max: 600 mg daily after an additional 7-day interval.
Epilepsy Initially 150 mg daily given as 2 or 3 divided doses, may be increased to 300 mg daily after 1 wk. Max: 600 mg daily after an additional wk.
GAD Initially 150 mg daily, may be increased to 300 mg daily after 1 wk. Following an additional wk, may be increased to 450 mg daily. Max: 600 mg daily after an additional wk.
Renal impairment CrCl ≥60 mL/min 150 mg bid or tid. Max: 600 mg daily;
≥30-<60 mL/min 75 mg bid or tid. Max: 300 mg daily;
≥15-<30 mL/min 25-50 mg once daily or bid. Max: 150 mg daily;
<15 mL/min 25 mg once daily. Max: 75 mg daily.
Supplementary dose following haemodialysis 25 mg as a single dose. Max: 300 mg daily.
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